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Gencode Genes

BIRC5 (ENST00000592734.5) at chr17:78214317-78222992 - Multitasking protein that has dual roles in promoting  cell proliferation and preventing apoptosis. Component of a  chromosome passage protein complex (CPC) which is essential for  chromosome alignment and segregation during mitosis and  cytokinesis. Acts as an important regulator of the localization of  this complex; directs CPC movement to different locations from the  inner centromere during prometaphase to midbody during cytokinesis  and participates in the organization of the center spindle by  associating with polymerized microtubules. The complex with RAN  plays a role in mitotic spindle formation by serving as a physical  scaffold to help deliver the RAN effector molecule TPX2 to  microtubules. May counteract a default induction of apoptosis in  G2/M phase. The acetylated form represses STAT3 transactivation of  target gene promoters. May play a role in neoplasia. Inhibitor of  CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play  vital roles in mitosis. Isoform 3 shows a marked reduction in its  anti-apoptotic effects when compared with the displayed wild-type  isoform. (from UniProt O15392)
BIRC5 (ENST00000590925.6) at chr17:78214263-78223554 - Multitasking protein that has dual roles in promoting  cell proliferation and preventing apoptosis. Component of a  chromosome passage protein complex (CPC) which is essential for  chromosome alignment and segregation during mitosis and  cytokinesis. Acts as an important regulator of the localization of  this complex; directs CPC movement to different locations from the  inner centromere during prometaphase to midbody during cytokinesis  and participates in the organization of the center spindle by  associating with polymerized microtubules. The complex with RAN  plays a role in mitotic spindle formation by serving as a physical  scaffold to help deliver the RAN effector molecule TPX2 to  microtubules. May counteract a default induction of apoptosis in  G2/M phase. The acetylated form represses STAT3 transactivation of  target gene promoters. May play a role in neoplasia. Inhibitor of  CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play  vital roles in mitosis. Isoform 3 shows a marked reduction in its  anti-apoptotic effects when compared with the displayed wild-type  isoform. (from UniProt O15392)